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KMID : 0371319770190070023
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Journal of the Korean Surgical Society
1977 Volume.19 No. 7 p.23 ~ p.28
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Combination Chemotherapy with Mitomycin C, 5-fluorouracil, and Cytosine Arabineside (MFC) for Stomach Cancer
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Kim Jin-Pok
Yang Jung-Hyun
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Abstract
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The combination of mitomycin C, 5-fluorouracil, and cytosine arabinoside (MFC) which had a marked synergistic effect was clinically used against advanced gastric cancer. Ota et. al. described a high response rate in cancer of the stomach (55%) and colon (60%) with MFC. The purpose of cancer chemotherapy as an adjuvant to surgery is the prevention of recurrence of cancer after the main tumor has been removed, even when the operation is only palliative.
MFC combination chemotherapy was used at Seoul National University Hospital in the trea-tment of 47 patients with stomach cancer since Oct. 1974. In these patients ad juvant chemotherapy MFG has been administered to 37 patients following radical surgery for stomach cancer. When with these patients were compared to patients treated by surgery alone, there was obvious improvement in recurrence and survival rates. 10 patients were treated with MFC following palliative surgery of stomach cancer. In these patients clinically useful responses were occurred in 4 patients.
Mitomycin.C (0.08mg/kg), 5-fluorourasil (10mg/kg) and cytosine arabinoside (0.8mg/kg) were given by I. V. twice weekly for 2 weeks, then once weekly for 6 weeks. The toxicity of MFC was bone marrow suppression and gastrointestinal symptoms, but the treatment can be expected to be a safe and useful treatment.
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KEYWORD
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